Description

1-(4-Chloro-Phenyl)-6-Fluoro-4-Oxo-7-Piperazin-1-Yl-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 100490-28-6. This compound is a critical building block in the synthesis of novel quinolone and naphthyridine-based antibacterial agents, offering significant value in modern drug discovery and development. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the production of next-generation antibiotics and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of potent antibacterial fluoroquinolone drugs.
• Antibacterial API Synthesis: Used in the research and commercial-scale manufacturing of active pharmaceutical ingredients targeting resistant bacterial strains.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the design of new antimicrobial agents.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and finished dosage forms.
• Biochemical Research: Utilized in biochemical assays to study bacterial DNA gyrase and topoisomerase IV inhibition mechanisms.
• Reference Standard: Acts as a high-purity analytical reference standard for quality control and regulatory compliance in API production.

Basic Information

Product Name	1-(4-Chloro-Phenyl)-6-Fluoro-4-Oxo-7-Piperazin-1-Yl-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid
CAS No.	100490-28-6
Molecular Formula	C20H16ClFN4O3
Molecular Weight	414.82 g/mol
Synonyms	1-(4-Chlorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 7-Piperazin-1-yl-1-(4-chlorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 100490-28-6; 1,8-Naphthyridine-3-carboxylic acid, 1-(4-chlorophenyl)-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-; 7-(1-Piperazinyl)-1-(4-chlorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-Phenyl)-6-Fluoro-4-Oxo-7-Piperazin-1-Yl-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.