Description

1,1-Diphenyl-4-(1-Pyrrolidinyl)-3-Buten-2-One Hydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. This compound is a critical building block in the synthesis of Efavirenz, a key active pharmaceutical ingredient (API) used in antiretroviral therapy for the treatment of HIV-1. It is essential for pharmaceutical manufacturers and advanced research institutions focused on developing and producing high-efficacy antiviral medications. The compound's specific stereochemistry and purity are paramount for ensuring the efficacy and safety of the final drug product.

Application

• Primary Intermediate for Efavirenz Synthesis: Serves as a crucial chiral precursor in the multi-step manufacturing process of the antiretroviral drug Efavirenz (Sustiva®).
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the discovery and optimization of new non-nucleoside reverse transcriptase inhibitors (NNRTIs).
• Active Pharmaceutical Ingredient (API) Production: Employed by contract manufacturing organizations (CMOs) and API producers for scale-up synthesis under cGMP conditions.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and impurity profiling related to Efavirenz.
• Academic Research: Applied in university and institutional studies investigating virology, drug resistance mechanisms, and novel antiviral strategies.

Basic Information

Product Name	1,1-Diphenyl-4-(1-Pyrrolidinyl)-3-Buten-2-One Hydrochloride
CAS No.	100482-65-3
Molecular Formula	C20H22ClNO
Molecular Weight	327.85 g/mol
Synonyms	(S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one Intermediate; Efavirenz Intermediate; DPC 961 Intermediate; L-743,726 Intermediate; Benzoxazinone Derivative; (4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2H-1,4-benzoxazin-3(4H)-one Precursor
EINECS	Contact for details

Quality Control

Our 1,1-Diphenyl-4-(1-Pyrrolidinyl)-3-Buten-2-One Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate use. We provide full traceability and detailed Certificates of Analysis (COA) that confirm identity, purity, and impurity profiles, supporting regulatory filings and cGMP compliance for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (S-enantiomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.