Description

7-Chloro-6-Fluoro-4-Oxo-1-Phenyl-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid Ethyl Ester is a high-purity pharmaceutical intermediate of significant commercial importance. This naphthyridine derivative serves as a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly quinolone-based antibacterial agents. It is essential for R&D laboratories and manufacturing facilities focused on developing and producing next-generation antimicrobial therapies.

Application

• Key Intermediate for Quinolone Antibiotics: A vital precursor in the synthesis of novel fluoroquinolone antibacterial agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new therapeutic compounds.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in multi-step synthetic routes to construct complex molecular frameworks for final API production.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry & Scale-Up: Utilized in optimizing synthetic pathways from laboratory scale to pilot plant and commercial manufacturing.

Basic Information

Product Name	7-Chloro-6-Fluoro-4-Oxo-1-Phenyl-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid Ethyl Ester
CAS No.	100426-74-2
Molecular Formula	C₁₇H₁₂ClFN₂O₃
Molecular Weight	346.74 g/mol
Synonyms	Ethyl 7-Chloro-6-fluoro-4-oxo-1-phenyl-1,4-dihydro-1,8-naphthyridine-3-carboxylate; 1,8-Naphthyridine-3-carboxylic acid, 7-chloro-6-fluoro-1,4-dihydro-4-oxo-1-phenyl-, ethyl ester; 7-Chloro-6-fluoro-1-phenyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester; 100426-74-2; Ethyl 7-chloro-6-fluoro-4-oxo-1-phenyl-1,4-dihydro[1,8]naphthyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our 7-Chloro-6-Fluoro-4-Oxo-1-Phenyl-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat and incompatible materials. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.