Description

Ethyl 6,7,8-Trifluoro-1-(Methylamino)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate is a high-purity fluorinated quinoline derivative, a critical advanced pharmaceutical intermediate (API) valued for its role in synthesizing novel active compounds. Its molecular structure, featuring a trifluoro-substituted quinoline core, makes it an essential building block for research and development in medicinal chemistry. This compound is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing next-generation therapeutics, particularly antimicrobial and anticancer agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone antibiotics and other bioactive molecules targeting bacterial DNA gyrase and topoisomerase IV.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities with potential therapeutic applications.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex APIs, where its specific substitution pattern is crucial for biological activity.
• Biochemical Research: Employed in biochemical assays and as a tool compound to study enzyme inhibition and cellular pathways.
• Fine Chemical Manufacturing: Utilized in the production of specialty chemicals for high-value, low-volume applications in the life sciences sector.

Basic Information

Product Name	Ethyl 6,7,8-Trifluoro-1-(Methylamino)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate
CAS No.	100276-66-2
Molecular Formula	C₁₃H₁₁F₃N₂O₃
Molecular Weight	300.24 g/mol
Synonyms	6,7,8-Trifluoro-1-(methylamino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester; Ethyl 6,7,8-trifluoro-1-methylamino-4-oxo-1,4-dihydro-3-quinolinecarboxylate; 1,4-Dihydro-6,7,8-trifluoro-1-(methylamino)-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester; 3-Quinolinecarboxylic acid, 1,4-dihydro-6,7,8-trifluoro-1-(methylamino)-4-oxo-, ethyl ester; CAS 100276-66-2
EINECS	Contact for details

Quality Control

Our Ethyl 6,7,8-Trifluoro-1-(Methylamino)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.