Description

4-Chloro-8-Nitroquinazoline is a versatile and high-value heterocyclic building block with significant synthetic utility. This compound is prized for its dual functional groups, which enable selective derivatization and incorporation into complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents, particularly in oncology research.
• Agrochemical Development: Serves as a core scaffold for creating novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Used in the development of organic semiconductors, ligands for metal-organic frameworks (MOFs), and photoactive compounds.
• Chemical Biology: Employed as a probe or tag in biochemical assays and for the development of enzyme inhibitors.
• Academic & Contract Research: Essential for methodological studies in organic synthesis, including cross-coupling and nucleophilic substitution reactions.
• Dye & Pigment Synthesis: Acts as an intermediate for the preparation of specialized quinazoline-based colorants.

Basic Information

Product Name	4-Chloro-8-Nitroquinazoline
CAS No.	19815-18-0
Molecular Formula	C8H4ClN3O2
Molecular Weight	209.59 g/mol
Synonyms	8-Nitro-4-chloroquinazoline; 4-Chloro-8-nitro-quinazoline; Quinazoline, 4-chloro-8-nitro-; 19815-18-0; 4-Chlor-8-nitrochinazolin (German); 4-クロロ-8-ニトロキナゾリン (Japanese)
EINECS	Contact for details

Quality Control

Our 4-Chloro-8-Nitroquinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.