Description

o-Acetyl-n-Methylhydroxylamine Hydrochloride is a versatile chemical building block and reagent, primarily valued for its role as a protected hydroxylamine derivative. This compound is crucial for introducing the N-methylhydroxylamine moiety into target molecules, enabling the synthesis of complex heterocycles and functionalized intermediates. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of oxazolidinone antibiotics and other N-O containing heterocyclic compounds with biological activity.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require the N-methylhydroxylamine functional group.
• Fine Chemical Production: Serves as a protected amine equivalent in multi-step organic synthesis for creating specialty chemicals and advanced materials.
• Bioconjugation & Linker Chemistry: Employed in the development of chemical probes, bioconjugates, and cleavable linkers for drug delivery systems.
• Academic & Industrial R&D: A fundamental research chemical for methodological development in organic synthesis and medicinal chemistry.
• Polymer Modification: Can be used to introduce functional groups into polymer chains to alter material properties.

Basic Information

Product Name	o-Acetyl-n-Methylhydroxylamine Hydrochloride
CAS No.	19689-95-3
Molecular Formula	C3H8ClNO2
Molecular Weight	125.55 g/mol
Synonyms	N-Methylacetohydroxamic Acid Hydrochloride; Acetamide, N-methoxy-, hydrochloride; N-Methoxyacetamide Hydrochloride; O-Acetyl-N-methylhydroxylamine HCl; N-Methyl-O-acetylhydroxylamine Hydrochloride; 1-(Methoxyamino)ethanone hydrochloride
EINECS	Contact for details

Quality Control

Our o-Acetyl-n-Methylhydroxylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay, impurity profile, and physical characteristics. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	~155-160 °C (dec.)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.