Description

H-Leu-Nhnh-Z Tfa is a protected amino acid derivative, specifically a leucine-based building block with a Z-protected hydrazide group and a trifluoroacetyl (Tfa) moiety. This compound is a critical intermediate in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure and reactivity. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug discovery, process development, and the production of specialized bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of leucine residues in complex peptide sequences.
• Pharmaceutical Intermediate: Used in the research and development of novel therapeutic peptides and protein-based drugs.
• Peptidomimetic Design: Serves as a precursor for creating non-peptide compounds that mimic the structure and function of natural peptides.
• Bioconjugation: The reactive hydrazide group enables site-specific conjugation to other molecules, such as drugs, dyes, or polymers.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	H-Leu-Nhnh-Z Tfa
CAS No.	19635-96-2
Molecular Formula	C17H23F3N4O5
Molecular Weight	420.38 g/mol
Synonyms	Nα-(Trifluoroacetyl)-Nε-(benzyloxycarbonyl)-L-lysine hydrazide; L-Leucine, N2-[(trifluoroacetyl)-N6-[(phenylmethoxy)carbonyl]-, hydrazide; Z-Lys(Tfa)-NHNH2; Nα-Trifluoroacetyl-Nε-carbobenzoxy-L-lysine hydrazide; N6-[(Benzyloxy)carbonyl]-N2-(trifluoroacetyl)-L-lysine hydrazide; (2S)-6-{[(Benzyloxy)carbonyl]amino}-2-[(2,2,2-trifluoroacetyl)amino]hexanoic acid hydrazide; Lys(Z,Tfa)-NHNH2
EINECS	Contact for details

Quality Control

Our H-Leu-Nhnh-Z Tfa is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to minimize oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.