Description

n-Benzyloxycarbonyl-o-Methylisourea is a versatile and high-purity chemical building block primarily used in organic synthesis and pharmaceutical research. This compound serves as a critical reagent for the introduction of the benzyloxycarbonyl (Cbz) protecting group, a fundamental operation in peptide and complex molecule synthesis. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for developing active pharmaceutical ingredients (APIs) and other advanced materials.

Application

• Peptide Synthesis: As a key reagent for the selective protection of amine functional groups via the Cbz (Z) group, crucial for solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediate: Used in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), particularly in oncology and neurology research.
• Organic Synthesis Building Block: Employed in the preparation of ureas, guanidines, and other nitrogen-containing heterocycles important for medicinal chemistry.
• Bioconjugation Chemistry: Facilitates the modification of biomolecules for drug delivery systems and diagnostic agent development.
• Polymer Chemistry: Can be utilized in the synthesis of functional polymers and dendrimers with specific amine-reactive sites.
• Chemical Biology Research: Serves as a tool compound for probing enzyme mechanisms and studying protein-protein interactions.

Basic Information

Product Name	n-Benzyloxycarbonyl-o-Methylisourea
CAS No.	19506-80-0
Molecular Formula	C10H12N2O2
Molecular Weight	192.21 g/mol
Synonyms	Z-Methylisourea; Benzyl N-(Methoxycarbonyl)carbamate; Cbz-Methylisourea; Benzyloxycarbonyl Methylisourea; N-Carbobenzyloxy-O-methylisourea; Methyl N-(Benzyloxycarbonyl)imidocarbonate; (Benzyloxycarbonyl)methylisourea; NSC 83653
EINECS	243-133-1

Quality Control

Our n-Benzyloxycarbonyl-o-Methylisourea is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.