Description

(1R,4R)-Methyl 4-Cyanocyclohexanecarboxylate is a high-purity, stereochemically defined chiral building block. This compound is a critical intermediate in the synthesis of complex pharmaceutical molecules, particularly those requiring a rigid, functionalized cyclohexane scaffold. It is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries developing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Asymmetric Synthesis: Used in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric catalysis.
• Fine Chemical Production: Employed in the multi-step synthesis of agrochemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & R&D: A valuable reagent for methodological development and exploration of new synthetic routes in organic chemistry laboratories.

Basic Information

Product Name	(1R,4R)-Methyl 4-Cyanocyclohexanecarboxylate
CAS No.	19145-95-0
Molecular Formula	C9H13NO2
Molecular Weight	167.21 g/mol
Synonyms	trans-Methyl 4-cyanocyclohexanecarboxylate; (1R,4R)-4-Cyano-cyclohexanecarboxylic acid methyl ester; Methyl (1R,4R)-4-cyanocyclohexane-1-carboxylate; Methyl trans-4-cyanocyclohexanecarboxylate; trans-4-Cyano-methyl cyclohexanecarboxylate; (R,R)-Methyl 4-cyanocyclohexanecarboxylate; 4-Cyano-methyl cyclohexanecarboxylate (trans-)
EINECS	Contact for details

Quality Control

Our (1R,4R)-Methyl 4-Cyanocyclohexanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.