Description

2-Hydroxymandelic Acid is a versatile aromatic hydroxy acid derivative of mandelic acid, serving as a key chiral building block and intermediate in advanced organic synthesis. Its significance lies in its bifunctional structure, featuring both a carboxylic acid and a phenolic hydroxyl group, which enables its use in the production of complex molecules and fine chemicals. This compound is essential for research and manufacturing in the pharmaceutical, agrochemical, and specialty chemical industries, where it is utilized in asymmetric synthesis and the development of active ingredients.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and cardiovascular diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Serves as a building block for flavors, fragrances, and advanced organic compounds requiring specific stereochemistry.
• Biochemical Research: Employed in enzymatic studies and as a standard or reagent in metabolic pathway analysis related to tyrosine metabolism.
• Cosmetic Ingredient Development: Investigated for use in skincare formulations due to its α-hydroxy acid (AHA) properties and potential antioxidant activity.
• Asymmetric Catalyst Ligand: The chiral center makes it a candidate for developing ligands used in asymmetric catalysis for enantioselective reactions.

Basic Information

Product Name	2-Hydroxymandelic Acid
CAS No.	19022-43-6
Molecular Formula	C8H8O4
Molecular Weight	168.15 g/mol
Synonyms	2-Hydroxymandelic Acid; (2-Hydroxyphenyl)glycolic Acid; 2-Hydroxy-2-phenylacetic Acid; 2-Phenyllactic Acid (Note: This is a common misnomer, 2-Hydroxymandelic is the correct name); α-Hydroxyphenylacetic Acid; o-Hydroxymandelic Acid; L-2-Hydroxymandelic Acid (for the L-enantiomer); DL-2-Hydroxymandelic Acid (for the racemic mixture)
EINECS	242-787-5

Quality Control

Our 2-Hydroxymandelic Acid is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, assay, impurity profile, and physical characteristics are provided and available upon request. We adhere to cGMP principles where applicable to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Specify: L-Form, D-Form, or Racemic (DL)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.