Description

4,5-Difluorophthalic Anhydride is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its role in introducing the phthalic anhydride moiety with strategic fluorine substitution, which can significantly alter the electronic and physical properties of target molecules. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries, particularly in the development of novel active ingredients and high-performance materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), where fluorine atoms enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Polymer & Material Science: Building block for fluorinated polyimides, epoxy resins, and other high-performance polymers that require enhanced thermal stability, chemical resistance, and low dielectric constants.
• Liquid Crystal & OLED Materials: Serves as a core component in the synthesis of fluorinated compounds for electronic display and lighting applications.
• Dyestuff & Pigment Intermediate: Employed in the production of specialized, color-fast fluorinated dyes and pigments.
• Cross-coupling Reactions: Useful substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck) for constructing complex fluorinated aromatic systems.

Basic Information

Product Name	4,5-Difluorophthalic Anhydride
CAS No.	18959-30-3
Molecular Formula	C8H2F2O3
Molecular Weight	184.10 g/mol
Synonyms	4,5-Difluorophthalic anhydride; 1,3-Dioxo-1,3-dihydroisobenzofuran-4,5-difluoride; 4,5-Difluoroisobenzofuran-1,3-dione; 4,5-Difluorophthalic acid anhydride; Difluorophthalic Anhydride; 18959-30-3; 4,5-Difluoro-1,3-dihydroisobenzofuran-1,3-dione
EINECS	Contact for details

Quality Control

Our 4,5-Difluorophthalic Anhydride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Single Impurity (HPLC)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.