Description

2,2,4,5,5-Pentamethyl-3-Imidazoline-3-Oxide-1-Oxyl, Free Radical is a stable nitroxide radical, widely recognized as a key spin label and spin trap in advanced research. This compound matters for its exceptional utility as a paramagnetic probe in electron paramagnetic resonance (EPR) spectroscopy and as a mediator in controlled radical polymerization processes. It is essential for researchers and manufacturers in polymer science, biochemistry, and materials science who require precise tools for studying molecular dynamics, kinetics, and polymer architecture.

Application

• Spin Labeling in EPR Spectroscopy: Used as a stable paramagnetic tag to study the structure, dynamics, and local environment of biomolecules, polymers, and complex materials.
• Spin Trapping Agent: Employed to detect and identify short-lived free radicals in chemical and biological systems, crucial for mechanistic studies in oxidation and degradation processes.
• Mediator for Nitroxide-Mediated Polymerization (NMP): Serves as a controlling agent in living/controlled radical polymerization to synthesize polymers with well-defined architectures and narrow molecular weight distributions.
• Polymer Stabilization: Acts as an antioxidant and radical scavenger to inhibit thermal and oxidative degradation in plastics and elastomers, extending material lifespan.
• Biophysical Research: Applied in membrane studies, protein folding analysis, and distance measurements using techniques like site-directed spin labeling (SDSL).
• Materials Science: Utilized in the development of functional materials, including organic magnets, molecular switches, and redox-active systems.
• Catalysis Research: Investigated as a catalyst or co-catalyst in oxidation reactions and organic synthesis.
• Reference Standard: Serves as a calibration standard in analytical chemistry and EPR instrumentation.

Basic Information

Product Name	2,2,4,5,5-Pentamethyl-3-Imidazoline-3-Oxide-1-Oxyl, Free Radical
CAS No.	18796-04-8
Molecular Formula	C8H15N2O2
Molecular Weight	171.22 g/mol
Synonyms	2,2,4,5,5-Pentamethyl-3-imidazoline-3-oxide-1-oxyl; 2,2,4,5,5-Pentamethyl-δ3-imidazoline-3-oxide-1-oxyl; 2,2,4,5,5-Pentamethylimidazolidine-1-oxyl; 2,2,4,5,5-Pentamethyl-3-imidazoline-1-oxyl-3-oxide; 4-Oxo-2,2,4,5,5-pentamethyl-3-imidazoline-1-oxyl; 4-Oxo-2,2,4,5,5-pentamethylimidazolidine-1-oxyl; 4-Oxo-TEMPO; 4-Oxo-2,2,6,6-tetramethylpiperidine-1-oxyl (common misnomer, related structure); 4-Oxo-TEMPO Free Radical
EINECS	Contact for details

Quality Control

Our production of 2,2,4,5,5-Pentamethyl-3-Imidazoline-3-Oxide-1-Oxyl adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and industrial applications. Each lot undergoes comprehensive analysis, including assay by HPLC, identity confirmation via IR and EPR spectroscopy, and quantification of key impurities. Certificates of Analysis (COA) detailing all test results are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, prolonged storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal long-term stability. Keep away from incompatible materials such as strong reducing agents.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (EPR)	Characteristic triplet signal
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.