Description

Diethyl 2-(4-Chlorobutyl)Malonate is a versatile organic building block and key synthetic intermediate. Its value lies in its bifunctional structure, featuring both a reactive chlorobutyl group and a malonate ester moiety, enabling diverse carbon-carbon bond-forming reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of complex molecules, active pharmaceutical ingredients (APIs), and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates and active pharmaceutical ingredients (APIs), especially those requiring the introduction of a functionalized butyl chain.
• Fine Chemical Synthesis: Used in the production of complex organic molecules, agrochemicals, and specialty materials where controlled alkylation is required.
• Building Block for Heterocycles: Serves as a starting material for the construction of nitrogen- and oxygen-containing heterocyclic compounds through cyclization reactions.
• Polymer Modification: Can be utilized to introduce functional groups into polymer backbones or as a monomer for specialty polymers with tailored properties.
• Organic Synthesis Research: Employed in academic and industrial R&D for developing new synthetic methodologies, particularly in nucleophilic substitution and malonate chemistry.

Basic Information

Product Name	Diethyl 2-(4-Chlorobutyl)Malonate
CAS No.	18719-44-3
Molecular Formula	C11H19ClO4
Molecular Weight	250.72 g/mol
Synonyms	Diethyl (4-chlorobutyl)malonate; 2-(4-Chlorobutyl)malonic Acid Diethyl Ester; Malonic Acid, (4-Chlorobutyl)-, Diethyl Ester; 4-Chlorobutylmalonic Acid Diethyl Ester; Diethyl 4-Chlorobutylmalonate; (4-Chlorobutyl)propanedioic Acid Diethyl Ester; Propanedioic Acid, (4-Chlorobutyl)-, 1,3-Diethyl Ester
EINECS	Contact for details

Quality Control

Our Diethyl 2-(4-Chlorobutyl)Malonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability, although the product is typically stable at controlled room temperature for shorter periods. Keep container tightly sealed when not in use to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.440 - 1.450
Density (g/mL at 20°C)	1.08 - 1.12

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.