Description

4-Bromo-2-(Trifluoromethyl)Quinoline is a high-purity, halogenated quinoline derivative serving as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in the unique reactivity imparted by the bromine and trifluoromethyl groups, enabling precise molecular construction for complex target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients, particularly where the introduction of fluorine atoms is required to modulate biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, where the quinoline scaffold and fluorine atoms contribute to herbicidal or insecticidal activity.
• Material Science Research: Serves as a precursor for creating functionalized organic materials, such as ligands for catalysts or components for organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl structures.
• Fluorine Chemistry: The trifluoromethyl group provides a source of fluorine for further derivatization, making it valuable in medicinal chemistry for optimizing drug-like properties.

Basic Information

Product Name	4-Bromo-2-(Trifluoromethyl)Quinoline
CAS No.	18706-25-7
Molecular Formula	C10H5BrF3N
Molecular Weight	276.06 g/mol
Synonyms	4-Bromo-2-(trifluoromethyl)quinoline; 2-(Trifluoromethyl)-4-bromoquinoline; Quinoline, 4-bromo-2-(trifluoromethyl)-; 4-Bromo-2-trifluoromethylquinoline; 18706-25-7; 4-Bromo-2-(trifluoromethyl)quinoline; 4-Bromo-2-trifluoromethyl-quinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.