Description

8-Chloro-4-Hydroxy-2-(Trifluoromethyl)Quinoline is a high-value, multifunctional heterocyclic building block distinguished by its unique trifluoromethyl and chloro substituents. This compound is essential for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its specific substitution pattern imparts critical electronic and steric properties. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds with enhanced bioactivity and stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinoline-based drug candidates, particularly for antimicrobial, anticancer, and anti-inflammatory applications.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Synthesis: Acts as a versatile scaffold for further functionalization in medicinal and combinatorial chemistry to create diverse chemical libraries.
• Fluorine Chemistry Studies: An important compound for research into the effects of fluorine substitution on the physical and chemical properties of heterocyclic systems.

Basic Information

Product Name	8-Chloro-4-Hydroxy-2-(Trifluoromethyl)Quinoline
CAS No.	18706-22-4
Molecular Formula	C₁₀H₅ClF₃NO
Molecular Weight	247.60 g/mol
Synonyms	8-Chloro-4-hydroxy-2-(trifluoromethyl)quinoline; 2-(Trifluoromethyl)-8-chloro-4-quinolinol; 4-Hydroxy-8-chloro-2-trifluoromethylquinoline; 8-Chloro-2-trifluoromethyl-4-quinolinol; 18706-22-4; Quinoline, 8-chloro-4-hydroxy-2-(trifluoromethyl)-; 8-Chloro-4-hydroxy-2-trifluoromethylquinoline
EINECS	Contact for details

Quality Control

Our 8-Chloro-4-Hydroxy-2-(Trifluoromethyl)Quinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.