Description

(3Ar)-3A,4,9,9Aα-Tetrahydro-4β-Hydroxy-6,7-Dimethoxy-9β-(3,4,5-Trimethoxyphenyl)Naphtho[2,3-C]Furan-1(3H)-One is a complex, high-purity organic compound belonging to the class of naphthofuran derivatives. This compound is valued for its sophisticated molecular architecture, which makes it a critical advanced intermediate in pharmaceutical research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) research.
• Chemical Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore and optimize biological activity profiles.
• Process Chemistry Development: Acts as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Academic & Institutional Research: Utilized in universities and research institutes for studies in organic synthesis, natural product analogs, and novel heterocyclic chemistry.

Basic Information

Item	Details
Product Name	(3Ar)-3A,4,9,9Aα-Tetrahydro-4β-Hydroxy-6,7-Dimethoxy-9β-(3,4,5-Trimethoxyphenyl)Naphtho[2,3-C]Furan-1(3H)-One
CAS No.	18651-67-7
Molecular Formula	C25H28O9
Molecular Weight	472.49 g/mol
Synonyms	Podophyllotoxin derivative; 4'-Demethyl-4-epipodophyllotoxin; 4'-Demethylepipodophyllotoxin; 4β-Hydroxy-6,7-dimethoxy-9β-(3,4,5-trimethoxyphenyl)-3a,4,9,9a-tetrahydro-1H-naphtho[2,3-c]furan-1-one; (3aR,4S,9R,9aS)-4-Hydroxy-6,7-dimethoxy-9-(3,4,5-trimethoxyphenyl)-3a,4,9,9a-tetrahydro-1H-naphtho[2,3-c]furan-1-one; 4'-Demethyl-4-epipodophyllotoxin; 4-Epipodophyllotoxin
EINECS	Contact for details

Quality Control

Our production of (3Ar)-3A,4,9,9Aα-Tetrahydro-4β-Hydroxy-6,7-Dimethoxy-9β-(3,4,5-Trimethoxyphenyl)Naphtho[2,3-C]Furan-1(3H)-One adheres to stringent quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.