Description

1,2-o-Isopropylidene-D-Glucofuranose is a key chiral intermediate and protected sugar derivative widely used in organic synthesis. This compound is valued for its role in constructing complex carbohydrate molecules and as a versatile building block for pharmaceuticals and fine chemicals. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity, stereochemically defined starting materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of nucleoside analogs, antiviral drugs, and other active pharmaceutical ingredients (APIs).
• Carbohydrate Chemistry: Serves as a protected glycosyl donor or acceptor in the synthesis of oligosaccharides, glycoconjugates, and complex natural products.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Acts as a building block for flavors, fragrances, and advanced material precursors.
• Biochemical Research: Employed in enzymatic studies and as a standard in analytical method development for sugar chemistry.

Basic Information

Product Name	1,2-o-Isopropylidene-D-Glucofuranose
CAS No.	18549-40-1
Molecular Formula	C9H16O6
Molecular Weight	220.22 g/mol
Synonyms	1,2:5,6-Di-O-isopropylidene-α-D-glucofuranose; Diacetone-D-glucose; Diacetone glucose; 1,2-O-Isopropylidene-α-D-glucofuranose; α-D-Glucofuranose, 1,2:5,6-bis-O-(1-methylethylidene)-; D-Glucose diethylidene acetal; (3aR,5R,6S,6aR)-5-[(R)-1,2-Dihydroxyethyl]-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol
EINECS	242-426-5

Quality Control

Our 1,2-o-Isopropylidene-D-Glucofuranose is produced under strict quality management systems. Each batch is tested to ensure high chemical purity and chiral integrity, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC/GC), optical rotation, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	-18.0° to -20.0° (c=1 in H₂O)
Melting Point	108°C - 112°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.