Description

4-Chloro-2-Fluoro-5-Nitrotoluene is a versatile halogenated aromatic intermediate of significant importance in advanced organic synthesis. Its value lies in its unique substitution pattern, which makes it a critical building block for constructing complex molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the nitro and halogen groups are essential for biological activity.
• Dye and Pigment Manufacturing: Acts as a starting material for synthesizing complex dyes and organic pigments due to its reactive nitro and halogen functional groups.
• Material Science Research: Employed in the development of novel organic electronic materials and liquid crystals.
• Cross-Coupling Reactions: A valuable substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups make it an excellent candidate for displacement reactions to introduce various nucleophiles.

Basic Information

Product Name	4-Chloro-2-Fluoro-5-Nitrotoluene
CAS No.	18349-11-6
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	1-Chloro-4-fluoro-2-methyl-5-nitrobenzene; 2-Fluoro-4-chloro-5-nitrotoluene; 5-Nitro-2-fluoro-4-chlorotoluene; Toluene, 4-chloro-2-fluoro-5-nitro-; 4-Chloro-2-fluoro-5-nitro-1-methylbenzene; 2-Methyl-4-chloro-5-nitrofluorobenzene; 4-Chloro-2-fluoro-5-nitromethylbenzene
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-5-Nitrotoluene is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and reducing agents. Recommended storage temperature is 2-8°C for long-term stability, although the product is stable at room temperature for shorter periods.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	65 - 68 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.