Description

[R,(-)]-1-o-Phosphono-D-Glycerol CAS NO 17989-41-2 is a high-purity, chiral phosphonic acid derivative of D-glycerol, serving as a critical biochemical building block and enzyme inhibitor. This compound is valued for its role in studying and modulating key metabolic pathways, particularly those involving glycerol phosphate. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require a reliable, high-quality intermediate for drug discovery, biochemical research, and the synthesis of specialized active pharmaceutical ingredients (APIs).

Application

• Biochemical Research: Acts as a potent and specific inhibitor of glycerol-3-phosphate dehydrogenase (GPDH) and other enzymes in glycerol phosphate metabolism.
• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel therapeutic agents, particularly for metabolic disorders.
• Enzyme Mechanism Studies: Used to probe the active sites and catalytic mechanisms of phosphatases, kinases, and dehydrogenases that interact with phosphorylated glycerol analogs.
• Metabolic Pathway Analysis: A valuable tool in cellular and molecular biology for disrupting and studying glycolysis, gluconeogenesis, and lipid biosynthesis pathways.
• Fine Chemical Synthesis: Employed in the asymmetric synthesis of complex molecules where the chiral phosphono-glycerol moiety is required.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	[R,(-)]-1-o-Phosphono-D-Glycerol
CAS No.	17989-41-2
Molecular Formula	C₃H₉O₆P
Molecular Weight	172.07 g/mol
Synonyms	(R)-(-)-1-O-Phosphono-D-glycerol; D-(-)-Glycerol 1-Phosphate; (R)-Glycerol 1-Phosphate; (2R)-2,3-Dihydroxypropyl Dihydrogen Phosphate; (R)-1-Phosphoglycerol; L-Glycerol 3-Phosphate (enantiomer); Glycerol 1-Phosphoric Acid; Phosphoric Acid Mono[(2R)-2,3-dihydroxypropyl] Ester
EINECS	Contact for details

Quality Control

Our [R,(-)]-1-o-Phosphono-D-Glycerol is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.