Description

(3S,10R,13S,14S,16R)-16-Bromo-10,13-Dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-Tetradecahydrospiro[Cyclopenta[A]Phenanthrene-17,2'-[1,3]Dioxolan]-3-Ol is a high-purity, advanced steroid intermediate characterized by its specific stereochemistry and bromine substitution. This compound is of significant value in pharmaceutical research and development, serving as a critical building block for the synthesis of complex bioactive molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for creating novel therapeutic agents and reference standards.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of steroid-based drugs, including potential anti-inflammatory, hormonal, and anticancer agents.
• Organic Synthesis Building Block: Utilized in complex multi-step syntheses to introduce specific stereocenters and functional groups into target molecules.
• Reference Standard: Serves as a high-purity analytical standard for method development, quality control, and regulatory submissions in pharmaceutical manufacturing.
• Biochemical Research: Used in academic and industrial laboratories to study steroid receptor interactions and metabolic pathways.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial steroid derivatives for client-specific research programs.

Basic Information

Product Name	(3S,10R,13S,14S,16R)-16-Bromo-10,13-Dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-Tetradecahydrospiro[Cyclopenta[A]Phenanthrene-17,2'-[1,3]Dioxolan]-3-Ol
CAS No.	17921-61-8
Molecular Formula	C22H31BrO3
Molecular Weight	423.39 g/mol
Synonyms	16-Bromo-3-hydroxy-spiro[estra-1,3,5(10)-triene-17,2'-[1,3]dioxolane]; 16α-Bromo-3β-hydroxy-5α-androstane-17,2'-[1,3]dioxolane] (and related systematic names); Brominated steroid dioxolane derivative; 17921-61-8; Steroid intermediate 17921-61-8; 16-Bromo steroid acetonide analog
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to verify identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. Our quality commitment aligns with the standards expected for GMP-grade intermediates and materials intended for pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Specific Rotation	Contact for details
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.