Description

(4-Benzyloxycarbonylaminophenyl)-Acetic Acid is a high-purity, protected amino acid derivative of significant value in advanced organic synthesis. This compound serves as a crucial building block for the construction of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating novel peptide-based therapeutics and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those with peptide or amide backbones.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid derivative, where the benzyloxycarbonyl (Cbz) group acts as a temporary protecting group for the amine functionality.
• Bioconjugation: Serves as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other targeted therapies.
• Protease Inhibitor Research: Employed in the design and synthesis of enzyme inhibitors targeting proteases and other hydrolytic enzymes.
• Chemical Biology Probes: Utilized to create labeled or modified peptides for studying protein-protein interactions and cellular pathways.
• Fine Chemical Synthesis: Acts as a versatile intermediate for the preparation of more complex, non-peptide aromatic acetic acid derivatives with potential biological activity.

Basic Information

Product Name	(4-Benzyloxycarbonylaminophenyl)-Acetic Acid
CAS No.	17859-70-0
Molecular Formula	C16H15NO4
Molecular Weight	285.29 g/mol
Synonyms	N-Cbz-4-Aminophenylacetic Acid; 4-[(Benzyloxycarbonyl)amino]benzenacetic Acid; [4-[(Phenylmethoxy)carbonylamino]phenyl]acetic Acid; 2-[4-[(Benzyloxycarbonyl)amino]phenyl]acetic Acid; N-Carbobenzoxy-4-aminophenylacetic Acid; Cbz-Phe(4-NH2)-OH (common peptide notation); Z-4-Aminophenylacetic Acid; 4-(N-Cbz-amino)phenylacetic Acid
EINECS	Contact for details

Quality Control

Our (4-Benzyloxycarbonylaminophenyl)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR, and IR for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.