Description

Tetramethylammonium Fluoride Tetrahydrate is a versatile and highly reactive quaternary ammonium fluoride salt. This compound serves as a powerful source of fluoride ions and a non-nucleophilic strong base, making it a critical reagent in advanced organic synthesis. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise fluorination and deprotection reactions.

Application

• Nucleophilic Fluorination Reactions: A key reagent for introducing fluorine atoms into organic molecules, crucial for developing pharmaceuticals and agrochemicals.
• Desilylation Agent: Efficiently removes silyl protecting groups (e.g., TMS, TBDMS) in complex multi-step organic syntheses.
• Catalyst and Promoter: Used as a catalyst or promoter in various organic transformations, including aldol condensations and Michael additions.
• Electrolyte Additive: Employed in the research and development of advanced battery systems, particularly for lithium-ion batteries.
• Etching and Surface Treatment: Applied in microfabrication and semiconductor manufacturing for precise etching processes.
• Polymer Chemistry: Acts as an initiator or catalyst in the polymerization of specific monomers.
• Analytical Chemistry: Serves as a derivatization agent or standard in chromatographic and spectroscopic methods.
• Material Science Research: Used in the synthesis of novel fluorinated materials and ionic liquids.

Basic Information

Product Name	Tetramethylammonium Fluoride Tetrahydrate
CAS No.	17787-40-5
Molecular Formula	C4H12FN · 4H2O
Molecular Weight	165.19 g/mol (anhydrous basis)
Synonyms	TMAF Tetrahydrate; Tetramethylammonium Fluoride 4-Hydrate; N,N,N-Trimethylmethanaminium Fluoride Tetrahydrate; Ammonium, tetramethyl-, fluoride, tetrahydrate; Fluorotetramethylammonium Tetrahydrate; TMAF·4H2O; F- N(CH3)4+ · 4H2O
EINECS	241-766-1

Quality Control

Our Tetramethylammonium Fluoride Tetrahydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms
Assay (Titration)	≥ 98.0 %
Water Content (KF)	20.0 - 25.0 %
Chloride (Cl)	≤ 0.1 %
Sulfate (SO4)	≤ 0.05 %
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.