Description

4-Nitrophenyl Trifluoromethanesulfonate is a high-purity, specialized chemical reagent widely used in advanced organic synthesis. This compound serves as a highly effective triflylating agent, enabling the introduction of the versatile trifluoromethanesulfonyl (triflyl) group into target molecules. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, facilitating the creation of complex intermediates and active ingredients. Its reactivity profile makes it a critical tool for constructing sulfonate esters and other functionalized aromatic systems under controlled conditions.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the preparation of sulfonamide derivatives and other active pharmaceutical ingredients (APIs) requiring the triflyl moiety.
• Agrochemical Research & Development: Used in creating novel herbicides, fungicides, and insecticides by acting as a precursor for sulfonyl-based compounds.
• Polymer & Material Science: Employed in the synthesis of specialty monomers and polymers, including those with sulfonate ester linkages for advanced material properties.
• Cross-Coupling Reactions: Serves as an electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl structures.
• Protecting Group Chemistry: Utilized to install the triflyl group as a protecting group for alcohols and phenols in multi-step synthetic sequences.
• Ligand & Catalyst Preparation: A precursor in the synthesis of specialized ligands and organometallic catalysts used in asymmetric synthesis.

Basic Information

Product Name	4-Nitrophenyl Trifluoromethanesulfonate
CAS No.	17763-80-3
Molecular Formula	C7H4F3NO5S
Molecular Weight	271.17 g/mol
Synonyms	p-Nitrophenyl Trifluoromethanesulfonate; p-Nitrophenyl Triflate; 4-Nitrophenyl Triflate; Trifluoromethanesulfonic Acid 4-Nitrophenyl Ester; 4-Nitrophenyl Trifluoromethylsulfonate; 1-Nitro-4-[(trifluoromethyl)sulfonyloxy]benzene; 4-Nitrophenyl Perfluoromethanesulfonate
EINECS	Contact for details

Quality Control

Our 4-Nitrophenyl Trifluoromethanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and industrial synthesis. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC to confirm identity and purity. Certificates of Analysis (COA) documenting all critical parameters are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.