Description

Z-Gly-His-Nhnh2 CAS NO 17682-11-0 is a specialized peptide derivative, specifically a protected tripeptide hydrazide. This compound is a crucial synthetic intermediate and biochemical tool, valued for its role in constructing more complex peptide structures and for its utility in bioconjugation and research applications. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in peptide synthesis, medicinal chemistry, and proteomics research.

Application

• Peptide Synthesis Intermediate: A key building block in solid-phase and solution-phase synthesis of larger, biologically active peptides.
• Bioconjugation Reagent: The hydrazide (Nhnh2) functional group enables selective conjugation to aldehydes and ketones, useful for labeling proteins, antibodies, or other biomolecules.
• Medicinal Chemistry Research: Serves as a precursor for developing peptide-based drug candidates, enzyme inhibitors, or diagnostic agents.
• Biochemical Tool Development: Used in the design and creation of affinity tags, enzyme substrates, or probes for studying biological processes.
• Protecting Group Strategy: The Z (benzyloxycarbonyl) group provides amine protection, allowing for controlled, sequential peptide chain elongation.

Basic Information

Product Name	Z-Gly-His-Nhnh2
CAS No.	17682-11-0
Molecular Formula	C18H24N8O5
Molecular Weight	432.43 g/mol
Synonyms	Nα-Benzyloxycarbonyl-glycyl-L-histidyl hydrazide; Z-Gly-His-NHNH2; CBZ-Gly-His-NHNH2; Glycyl-L-histidyl hydrazide, N-[(benzyloxy)carbonyl]-; Benzyl N-[(benzyloxy)carbonyl]glycyl-L-histidylhydrazinecarboxylate (related form); Z-Gly-His Hydrazide; N-CBZ-Glycyl-L-histidyl hydrazide
EINECS	Contact for details

Quality Control

Our Z-Gly-His-Nhnh2 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and related substances is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.