Description

7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-3-Hydroxy-2H-1,4-Benzodiazepin-2-One is a high-purity pharmaceutical intermediate belonging to the benzodiazepine class of compounds. This compound is of critical importance for its role as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) and for research into central nervous system (CNS) therapeutics. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical producers engaged in the development and production of specialty drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel benzodiazepine-derived active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new therapeutic agents targeting neurological pathways.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Process Chemistry: Employed in route scouting and process optimization for the scalable manufacturing of complex drug molecules.
• Biochemical Research: Utilized as a ligand or probe in biochemical assays to study receptor binding and enzyme interactions related to the benzodiazepine site.

Basic Information

Product Name	7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-3-Hydroxy-2H-1,4-Benzodiazepin-2-One
CAS No.	17617-60-6
Molecular Formula	C₁₅H₁₀ClFN₂O₂
Molecular Weight	304.70 g/mol
Synonyms	3-Hydroxy-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-; 17617-60-6; 3-Hydroxynorfludiazepam; Norfludiazepam 3-hydroxy derivative
EINECS	Contact for details

Quality Control

Our 7-Chloro-5-(2-Fluorophenyl)-1,3-Dihydro-3-Hydroxy-2H-1,4-Benzodiazepin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR), to ensure compliance with stringent in-house specifications suitable for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.