Description

10-Hydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene is a significant hydroxylated metabolite and a key intermediate in the study of polycyclic aromatic hydrocarbon (PAH) metabolism and carcinogenesis. Its value lies in providing researchers with a critical tool for investigating the metabolic activation pathways, DNA adduct formation, and detoxification mechanisms of benzo(a)pyrene, a well-known environmental carcinogen. This compound is essential for toxicology research, environmental monitoring studies, and the development of analytical standards for detecting PAH exposure in biological systems.

Application

• Biochemical Research: Used as a reference standard and metabolic intermediate in studies of benzo(a)pyrene metabolism and activation pathways.
• Toxicology & Carcinogenesis Studies: Critical for investigating the mechanisms of PAH-induced DNA damage, mutagenicity, and cancer initiation.
• Analytical Chemistry: Serves as a high-purity standard for calibrating equipment (HPLC, GC-MS, LC-MS) in environmental and biological monitoring of PAH metabolites.
• Environmental Science: Employed in research to understand the fate, biotransformation, and biomarker development for PAH pollution in ecosystems.
• Pharmaceutical Research: Used in studies exploring enzyme kinetics of cytochrome P450 and other metabolizing enzymes involved in xenobiotic processing.
• Academic & Institutional Laboratories: A fundamental reagent for graduate-level research and published studies in chemistry, biochemistry, and environmental health sciences.

Basic Information

Product Name	10-Hydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene
CAS No.	17573-24-9
Molecular Formula	C₂₀H₁₆O
Molecular Weight	272.34 g/mol
Synonyms	10-Hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene; 10-Hydroxy-7,8,9,10-tetrahydro-BaP; 10-Hydroxy-7,8,9,10-tetrahydrobenzopyrene; Benzo[a]pyrene-10-ol, 7,8,9,10-tetrahydro-; 10-Hydroxy-tetrahydro-benzo(a)pyrene; 10-Hydroxy-TH-BaP; BaP-10-ol (tetrahydro); 10-Hydroxy-7,8,9,10-tetrahydrobenzo(def)chrysene
EINECS	Contact for details

Quality Control

Our 10-Hydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing under inert atmosphere at lower temperatures (-20°C) to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light tan powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.