Description

(R)-(+)-2-Chloro-3-[4(5)-Imidazolyl]Propionic Acid CAS NO 17561-27-2 is a high-purity chiral intermediate featuring a reactive chloropropionic acid moiety attached to an imidazole heterocycle. This compound is of significant value for the synthesis of enantiomerically pure pharmaceuticals and bioactive molecules, particularly those targeting histamine or purinergic receptors. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for developing new active pharmaceutical ingredients (APIs) and advanced ligands.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of histamine H3 receptor antagonists and other receptor-targeting drugs.
• Biochemical Research: Used in proteomics and enzymology studies as a tool compound or for synthesizing enzyme inhibitors.
• Agrochemical Synthesis: Intermediate in the development of novel, chiral fungicides or herbicides with specific modes of action.
• Ligand Synthesis: Preparation of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptide Mimetics: Incorporation into peptide analogs to modulate biological activity and stability.
• Diagnostic Agent Development: Potential precursor for radiolabeled compounds used in medical imaging.

Basic Information

Product Name	(R)-(+)-2-Chloro-3-[4(5)-Imidazolyl]Propionic Acid
CAS No.	17561-27-2
Molecular Formula	C6H7ClN2O2
Molecular Weight	174.59 g/mol
Synonyms	(R)-2-Chloro-3-(1H-imidazol-4-yl)propanoic acid; (R)-2-Chloro-3-(1H-imidazol-5-yl)propionic acid; (R)-(+)-2-Chloro-3-(4-imidazolyl)propionic acid; (R)-α-Chloro-β-(4-imidazolyl)propionic acid; (R)-CIP; (R)-Histidine chloromethyl ketone analog; (R)-2-Chloro-3-(1H-imidazol-4-yl)propanoate
EINECS	Contact for details

Quality Control

Our (R)-(+)-2-Chloro-3-[4(5)-Imidazolyl]Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.