Description

(S)-5,5A,6,7-Tetrahydro-8-Hydroxy-3,5A,9-Trimethylnaphtho[1,2-B]Furan-2(4H)-One is a high-purity, chiral organic compound belonging to the class of substituted naphthofuranones. This molecule is of significant interest in advanced organic synthesis and pharmaceutical research, particularly as a key chiral building block or intermediate for complex active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Asymmetric Synthesis: Used as a starting material or reagent in stereoselective reactions to construct molecules with high enantiomeric purity, leveraging its defined (S)-configuration.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities within the naphthofuranone pharmacophore.
• Agrochemical Development: Investigated as a potential intermediate for creating novel pesticides or herbicides with specific chiral activity.
• Fine Chemical Production: Acts as a specialized building block for synthesizing fragrances, dyes, or other high-value performance chemicals requiring precise stereochemistry.
• Reference Standard: Supplied as a high-purity analytical standard for quality control (QC) and method development in analytical laboratories.

Basic Information

Product Name	(S)-5,5A,6,7-Tetrahydro-8-Hydroxy-3,5A,9-Trimethylnaphtho[1,2-B]Furan-2(4H)-One
CAS No.	17453-65-5
Molecular Formula	C₁₇H₂₂O₃
Molecular Weight	274.35 g/mol
Synonyms	(S)-8-Hydroxy-3,5a,9-trimethyl-2,4,5,5a,6,7-hexahydronaphtho[1,2-b]furan-2-one; (S)-(-)-8-Hydroxy-3,5a,9-trimethyl-5,5a,6,7-tetrahydro-2H-naphtho[1,2-b]furan-2-one; (S)-(-)-8-Hydroxy-3,5a,9-trimethyl-5,5a,6,7-tetrahydro-2H-naphtho[1,2-b]furan-2-one; (S)-5,5a,6,7-Tetrahydro-8-hydroxy-3,5a,9-trimethylnaphtho[1,2-b]furan-2(4H)-one; (S)-(-)-5,5a,6,7-Tetrahydro-8-hydroxy-3,5a,9-trimethylnaphtho[1,2-b]furan-2(4H)-one; (S)-(-)-8-Hydroxy-3,5a,9-trimethyl-5,5a,6,7-tetrahydro-2H-naphtho[1,2-b]furan-2-one; (S)-(-)-8-Hydroxy-3,5a,9-trimethyl-5,5a,6,7-tetrahydro-2H-naphtho[1,2-b]furan-2-one; (S)-(-)-8-Hydroxy-3,5a,9-trimethyl-5,5a,6,7-tetrahydro-2H-naphtho[1,2-b]furan-2-one
EINECS	Contact for details

Quality Control

Our (S)-5,5A,6,7-Tetrahydro-8-Hydroxy-3,5A,9-Trimethylnaphtho[1,2-B]Furan-2(4H)-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to meet the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.