Description

(E)-Ethyl 2-Oxo-4-Phenylbut-3-Enoate is a high-purity, versatile α,β-unsaturated ester building block essential for advanced organic synthesis. Its conjugated ketone-ester structure makes it a critical intermediate for constructing complex molecular frameworks with high regio- and stereoselectivity. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in heterocyclic chemistry and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of biologically active molecules, including potential enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the development of novel active ingredients for crop protection products, leveraging its reactivity for ring formation.
• Fine Chemical Production: Serves as a building block for fragrances, flavors, and specialty polymers requiring specific olefinic motifs.
• Academic & Industrial R&D: Employed in methodological studies for Michael additions, cycloadditions, and other carbon-carbon bond-forming reactions.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating polymers with tailored optical or electronic properties.

Basic Information

Product Name	(E)-Ethyl 2-Oxo-4-Phenylbut-3-Enoate
CAS No.	17451-20-6
Molecular Formula	C₁₂H₁₂O₃
Molecular Weight	204.22 g/mol
Synonyms	Ethyl (E)-2-Oxo-4-phenyl-3-butenoate; (E)-Ethyl 2-Oxo-4-phenyl-3-butenoate; Ethyl 2-Oxo-4-phenylbut-3-enoate; trans-Ethyl 2-Oxo-4-phenyl-3-butenoate; 3-Butenoic acid, 2-oxo-4-phenyl-, ethyl ester, (E)-; Ethyl benzylideneacetoacetate; Ethyl (E)-α-(benzylidene)acetoacetate; Ethyl α-benzylideneacetoacetate
EINECS	Contact for details

Quality Control

Our (E)-Ethyl 2-Oxo-4-Phenylbut-3-Enoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and isomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
(E)-Isomer Content (HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.