Description

7-Bromo-6-Chloro-3-[3-(3-Hydroxy-2-Piperidyl)-2-Oxopropyl]Quinazolin-4(3H)-One Monohydrobromide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure, essential for research and development in modern drug discovery. Its primary value lies in serving as a critical building block for synthesizing novel therapeutic agents, particularly kinase inhibitors and other targeted small-molecule drugs. This compound is specifically needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and academic institutions focused on oncology and signal transduction pathway research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step production of targeted cancer therapeutics and kinase inhibitors.
• Drug Discovery Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Biochemical Tool Compound: Serves as a reference standard or a starting material for developing biochemical probes to study specific enzyme functions.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Academic Research: Utilized in university and institutional labs for investigating novel quinazolinone-based compounds and their biological activities.

Basic Information

Product Name	7-Bromo-6-Chloro-3-[3-(3-Hydroxy-2-Piperidyl)-2-Oxopropyl]Quinazolin-4(3H)-One Monohydrobromide
CAS No.	17395-31-2
Molecular Formula	C₁₆H₁₈BrClN₃O₃ • HBr
Molecular Weight	508.60 g/mol
Synonyms	7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]-3,4-dihydroquinazolin-4-one hydrobromide; 7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]quinazolin-4-one HBr; 17395-31-2; Quinazolin-4(3H)-one, 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-, monohydrobromide; Monohydrobromide salt of 7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]quinazolin-4(3H)-one
EINECS	Contact for details

Quality Control

Our 7-Bromo-6-Chloro-3-[3-(3-Hydroxy-2-Piperidyl)-2-Oxopropyl]Quinazolin-4(3H)-One Monohydrobromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.