Description

(E)-4'-Bromo-β-Chloroacrylophenone CAS NO 17306-04-6 is a high-purity, halogenated acrylophenone derivative characterized by its distinct (E)-stereochemistry and reactive α,β-unsaturated carbonyl system. This compound serves as a versatile and critical pharmaceutical intermediate and organic synthesis building block, enabling the construction of complex molecular architectures. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory pathways.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Chemical Research (R&D): Used in academic and industrial R&D for exploring new organic reactions, such as Michael additions and cyclization reactions, due to its electrophilic alkene moiety.
• Material Science: Intermediate in the production of specialty polymers and liquid crystal materials, leveraging its rigid, aromatic structure.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for creating biaryl structures, facilitated by the bromo substituent.

Basic Information

Product Name	(E)-4'-Bromo-β-Chloroacrylophenone
CAS No.	17306-04-6
Molecular Formula	C9H6BrClO
Molecular Weight	245.50 g/mol
Synonyms	(E)-1-(4-Bromophenyl)-3-chloroprop-2-en-1-one; 4'-Bromo-3-chloroacrylophenone; (E)-3-Chloro-1-(4-bromophenyl)-2-propen-1-one; 1-(4-Bromophenyl)-3-chloro-2-propen-1-one; (E)-4'-Bromo-β-chlorochalcone; 4-Bromo-β-chloroacrylophenone; p-Bromo-β-chloroacrylophenone; (E)-4-Bromophenyl 3-chloropropenyl ketone
EINECS	Contact for details

Quality Control

Our (E)-4'-Bromo-β-Chloroacrylophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent isomeric integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong bases and reducing agents. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isomeric Purity ((E)-isomer)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.