Description

(S)-(-)-α-Methoxy-α-(Trifluoromethyl)Phenylacetic Acid CAS NO 17257-71-5 is a high-value chiral derivatizing agent and resolving acid, essential for the determination of enantiomeric purity. Its primary value lies in its ability to form stable diastereomeric derivatives with chiral amines and alcohols, enabling precise analysis via NMR or chromatography. This compound is critically needed by pharmaceutical R&D laboratories, analytical service providers, and fine chemical manufacturers involved in asymmetric synthesis and quality control of chiral intermediates.

Application

• Chiral derivatizing agent for the determination of enantiomeric excess (ee) of amines, amino alcohols, and other basic compounds via NMR spectroscopy or HPLC analysis.
• Key resolving agent in the classical diastereomeric salt formation method for the purification of chiral pharmaceutical intermediates.
• Building block for the synthesis of advanced chiral ligands and organocatalysts used in asymmetric transformations.
• Reference standard and reagent in analytical method development for regulatory compliance in drug manufacturing (ICH guidelines).
• Research chemical for studying stereochemistry and reaction mechanisms in academic and industrial R&D.
• Intermediate in the preparation of specialty chemicals with applications in agrochemicals and material science.

Basic Information

Product Name	(S)-(-)-α-Methoxy-α-(Trifluoromethyl)Phenylacetic Acid
CAS No.	17257-71-5
Molecular Formula	C11H9F3O3
Molecular Weight	246.18 g/mol
Synonyms	(S)-MTPA; (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid; (S)-Mosher's acid; L-MTPA; (S)-2-Methoxy-2-(trifluoromethyl)phenylacetic acid; (S)-α-Methoxy-α-trifluoromethylphenylacetic acid; (S)-O-Methylmandelic acid α-trifluoromethyl derivative; (S)-(-)-Methoxy(trifluoromethyl)phenylacetic acid
EINECS	Contact for details

Quality Control

Our (S)-(-)-α-Methoxy-α-(Trifluoromethyl)Phenylacetic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity assay by HPLC, to ensure it meets the high standards required for analytical and synthetic applications. Certificates of Analysis (COA) detailing specific results for chiral purity, chemical purity, and identity are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Melting Point	Contact for details
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.