Description

(4R,5S)-2,2,4,5-Tetramethyl-1,3-Dioxolane is a high-purity, chiral dioxolane derivative with significant utility as a versatile building block and chiral auxiliary in organic synthesis. Its value lies in its defined stereochemistry and structural framework, which are critical for inducing stereoselectivity in complex chemical transformations. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular architecture is paramount for developing active ingredients and advanced materials.

Application

• As a chiral auxiliary or ligand in asymmetric synthesis for pharmaceuticals.
• Key intermediate in the production of fine chemicals and complex organic molecules.
• Building block for fragrance and flavor compounds requiring specific stereoisomers.
• Solvent or co-solvent in specialized chemical reactions and formulations.
• Starting material for polymer chemistry and material science applications.
• Used in academic and industrial R&D for method development and catalysis studies.

Basic Information

Product Name	(4R,5S)-2,2,4,5-Tetramethyl-1,3-Dioxolane
CAS No.	17226-65-2
Molecular Formula	C7H14O2
Molecular Weight	130.18 g/mol
Synonyms	(4R,5S)-2,2,4,5-Tetramethyl-1,3-dioxolane; (4R-cis)-2,2,4,5-Tetramethyl-1,3-dioxolane; (4R,5S)-4,5-Dimethyl-2,2-dimethyl-1,3-dioxolane; D-(-)-2,3-Isopropylidene-1,4-dihydroxybutane; (R,R)-(-)-2,3-O-Isopropylidene-L-threitol cyclic acetal; 1,3-Dioxolane, 2,2,4,5-tetramethyl-, (4R,5S)-; L-Threitol, 2,3-O-isopropylidene-, (R,R)-(-)-
EINECS	Contact for details

Quality Control

Our (4R,5S)-2,2,4,5-Tetramethyl-1,3-Dioxolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by GC or HPLC, to ensure compliance with exacting specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Chiral Purity (GC/HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.