Description

1,4-Dioxaspiro[4.5]Decan-8-Ylmethanol is a versatile spirocyclic compound featuring a protected diol moiety and a hydroxymethyl functional group, making it a valuable chiral building block in advanced organic synthesis. Its unique structure provides a rigid, stereodefined scaffold that is critical for constructing complex molecules with high precision. This intermediate is essential for research and production in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, including antiviral agents, central nervous system (CNS) drugs, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that require a spirocyclic framework.
• Material Science Research: Acts as a monomer or building block for novel polymers and functional materials with specific architectural properties.
• Academic & R&D: A valuable compound for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	1,4-Dioxaspiro[4.5]Decan-8-Ylmethanol
CAS No.	17159-82-9
Molecular Formula	C10H18O3
Molecular Weight	186.25 g/mol
Synonyms	8-(Hydroxymethyl)-1,4-dioxaspiro[4.5]decane; 1,4-Dioxaspiro[4.5]decan-8-ylmethanol; 8-Hydroxymethyl-1,4-dioxaspiro[4.5]decane; Spiro[1,3-dioxolane-2,1'-cyclohexane]-4'-methanol; Cyclohexanemethanol, 1,3-dioxolane deriv.; (1,4-Dioxaspiro[4.5]dec-8-yl)methanol
EINECS	Contact for details

Quality Control

Our 1,4-Dioxaspiro[4.5]Decan-8-Ylmethanol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC/GC purity, chiral purity, and identity confirmation (IR, NMR). A detailed Certificate of Analysis (COA) is supplied with each batch, documenting all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (if applicable)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.