Description

4-Maleimidobenzoic Acid is a high-purity bifunctional organic compound featuring both a carboxylic acid and a maleimide group, making it a versatile heterobifunctional crosslinker. This compound is critical for creating stable covalent bonds between amine and thiol-containing molecules, such as proteins and peptides, under mild conditions. It is an essential building block for researchers and manufacturers in the bioconjugation, pharmaceutical development, and advanced materials sectors, particularly for antibody-drug conjugate (ADC) synthesis and polymer modification.

Application

• Bioconjugation Reagent: A key heterobifunctional crosslinker for coupling antibodies, proteins, or peptides with drugs, enzymes, or other biomolecules via amine-thiol chemistry.
• Antibody-Drug Conjugate (ADC) Development: Used in the synthesis of linker-payload constructs, connecting cytotoxic drugs to monoclonal antibodies for targeted cancer therapies.
• Surface Functionalization: Modifies surfaces (e.g., nanoparticles, chips, beads) with maleimide groups for the specific immobilization of thiolated biomolecules in biosensor and diagnostic assay development.
• Polymer Chemistry: Serves as a monomer or modifier for synthesizing functional polymers, hydrogels, and smart materials with responsive or bioactive properties.
• Peptide Synthesis & Modification: Used to introduce maleimide handles onto peptides for site-specific labeling or cyclization.
• Protein Labeling & Tracking: Facilitates the attachment of fluorescent dyes, biotin, or other probes to proteins for imaging, detection, and purification studies.

Basic Information

Product Name	4-Maleimidobenzoic Acid
CAS No.	17057-04-4
Molecular Formula	C11H7NO4
Molecular Weight	217.18 g/mol
Synonyms	4-Maleimidobenzoic Acid; p-Maleimidobenzoic Acid; 4-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)benzoic Acid; 1H-Pyrrole-1-carboxylic acid, 2,5-dihydro-2,5-dioxo-, 4-carboxyphenyl ester; 4-MBA; MBA; 4-(Maleimido)benzoic acid; Maleimidobenzoic acid
EINECS	241-155-9

Quality Control

Our 4-Maleimidobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity. Keep the container sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.