Description

Diethyl(1,3-Dioxolan-2-Ylmethyl)Phosphonate is a high-value organophosphorus compound, specifically a phosphonate ester, that serves as a versatile building block in advanced organic synthesis. Its core value lies in its ability to act as a key reagent in the Horner-Wadsworth-Emmons (HWE) olefination reaction, enabling the efficient and stereoselective formation of carbon-carbon double bonds. This makes it an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to construct complex molecular frameworks for active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those containing α,β-unsaturated carbonyl moieties or complex olefin structures.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators that require specific alkene geometries for optimal biological activity.
• Specialty Chemical Manufacturing: Employed as a key building block for creating fine chemicals, liquid crystals, polymers, and other functional materials with tailored properties.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in organic chemistry and for the discovery of novel compounds in research settings.
• Flavor & Fragrance Industry: Can be utilized in the synthesis of certain aroma chemicals that rely on specific alkene intermediates.

Basic Information

Product Name	Diethyl(1,3-Dioxolan-2-Ylmethyl)Phosphonate
CAS No.	17053-09-7
Molecular Formula	C8H17O5P
Molecular Weight	224.19 g/mol
Synonyms	Diethyl (1,3-dioxolan-2-ylmethyl)phosphonate; (1,3-Dioxolan-2-ylmethyl)phosphonic acid diethyl ester; 2-(Diethoxyphosphorylmethyl)-1,3-dioxolane; Diethyl [(1,3-dioxolan-2-yl)methyl]phosphonate; Acetaldehyde ethylene acetal diethyl phosphonate; Glycidaldehyde diethyl acetal phosphonate; (2-Formyl-1,3-dioxolan-4-yl)methyl diethyl phosphonate (related precursor); HWE Reagent derivative
EINECS	Contact for details

Quality Control

Our Diethyl(1,3-Dioxolan-2-Ylmethyl)Phosphonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC/GC) and spectroscopy (NMR, IR), to ensure high chemical purity and identity confirmation. We provide detailed Certificates of Analysis (COA) with every shipment, documenting key parameters such as assay and impurity profiles. Our quality systems are designed to support cGMP manufacturing for pharmaceutical applications where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.435 - 1.445
Density (20°C)	1.15 - 1.20 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.