Description

1-Chlorosulfonyl-3-Methyl-1-Azaspiro[3.5]Nonan-2-One is a high-value, advanced pharmaceutical intermediate characterized by its unique spirocyclic and chlorosulfonyl functional groups. This compound is critical for synthetic chemists developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing sophisticated heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those with spirocyclic or constrained ring systems for enhanced biological activity and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the chlorosulfonyl group acts as a versatile handle for further derivatization.
• Chemical Biology Probe Development: Serves as a precursor for creating covalent inhibitors or activity-based probes that target specific enzymes, leveraging its reactive sulfonyl chloride moiety.
• Material Science Research: Employed in the synthesis of specialized polymers or functional materials that incorporate heterocyclic units for specific thermal or chemical properties.

Basic Information

Product Name	1-Chlorosulfonyl-3-Methyl-1-Azaspiro[3.5]Nonan-2-One
CAS No.	16933-89-4
Molecular Formula	C9H14ClNO3S
Molecular Weight	251.73 g/mol
Synonyms	3-Methyl-1-azaspiro[3.5]nonane-1,2-dione 1-sulfonyl chloride; 3-Methyl-1-azaspiro[3.5]nonane-2-one-1-sulfonyl chloride; 1-Azaspiro[3.5]nonane-2-one, 1-(chlorosulfonyl)-3-methyl-; 1-Chlorosulfonyl-3-methyl-1-azaspiro[3.5]nonan-2-one; 3-Methyl-1-(chlorosulfonyl)-1-azaspiro[3.5]nonan-2-one
EINECS	Contact for details

Quality Control

Our production of 1-Chlorosulfonyl-3-Methyl-1-Azaspiro[3.5]Nonan-2-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.