Description

3,4,6-Tri-o-Methyl-D-Glucal, 97% is a high-purity, protected carbohydrate derivative, specifically a methylated glucal, serving as a versatile chiral synthon and key intermediate in organic synthesis. Its primary value lies in enabling stereoselective glycosylation and the construction of complex sugar-based molecules, which are critical for pharmaceutical and biochemical research. This compound is essential for R&D chemists and process development scientists working in pharmaceutical development, particularly for nucleoside analogs and carbohydrate-based drugs, as well as in academic research exploring glycoscience and synthetic methodology.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Glycosylation Reagent: Used in stereoselective glycosylation reactions to construct complex oligosaccharides and glycoconjugates.
• Chiral Pool Synthesis: Serves as a starting material from the chiral pool for the asymmetric synthesis of natural products and other bioactive molecules.
• Carbohydrate Chemistry Research: A fundamental tool in academic and industrial labs for studying glycosylation mechanisms and developing new synthetic routes to sugars.
• Glycomimetics Development: Used to create sugar mimics (glycomimetics) for drug discovery programs targeting enzymes like glycosidases and glycosyltransferases.
• Protecting Group Strategy: The methyl ether protecting groups provide stability, making it a valuable intermediate in multi-step synthetic sequences requiring orthogonal deprotection.

Basic Information

Product Name	3,4,6-Tri-o-Methyl-D-Glucal, 97%
CAS No.	16740-98-0
Molecular Formula	C9H16O5
Molecular Weight	204.22 g/mol
Synonyms	3,4,6-Tri-O-methyl-D-glucal; D-Glucal, 3,4,6-tris-O-methyl-; 1,5-Anhydro-2-deoxy-3,4,6-tri-O-methyl-D-arabino-hex-1-enitol; Tri-O-methyl-D-glucal; Methylated D-Glucal; 3,4,6-Trimethyl-D-glucal; 2-Deoxy-3,4,6-tri-O-methyl-D-glucose ethylene acetal (related)
EINECS	240-803-5

Quality Control

Our 3,4,6-Tri-o-Methyl-D-Glucal, 97% is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the specified 97% minimum purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant quality parameters for your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.