Description

n-Acetoacetylmorpholine (CAS NO 16695-54-8) is a versatile acetoacetamide derivative and a key reactive intermediate in organic synthesis. Its primary value lies in its bifunctional structure, featuring both a reactive methylene group and an amide linkage, making it an essential building block for heterocyclic chemistry. This compound is particularly valuable for manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop advanced molecules with specific performance characteristics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of various heterocyclic compounds, including pyrazoles and pyrimidines, which are core structures in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where its morpholine ring can contribute to systemic activity and bioavailability.
• Dye and Pigment Manufacturing: Serves as a coupling agent and intermediate in the synthesis of high-performance organic pigments and dyes, particularly azo pigments.
• Polymer Additives: Acts as a cross-linking agent or a modifier in polymer systems to enhance specific properties like thermal stability or adhesion.
• Chemical Research & Development: Employed as a versatile reagent in academic and industrial R&D for constructing complex molecular architectures and exploring new synthetic pathways.
• Coordination Chemistry: Can function as a ligand or precursor for metal-organic frameworks (MOFs) and catalysts due to its carbonyl and amide functional groups.

Basic Information

Product Name	n-Acetoacetylmorpholine
CAS No.	16695-54-8
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	Acetoacetic Acid Morpholide; 3-Oxobutanoyl Morpholine; 4-Acetoacetylmorpholine; Morpholino Butanone; N-(3-Oxobutanoyl)morpholine; Acetoacetmorpholide; 1-Morpholinobutan-1,3-dione; AAM
EINECS	240-759-6

Quality Control

Our n-Acetoacetylmorpholine is produced under a stringent quality management system to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including identity confirmation by FT-IR and NMR, and purity determination by GC or HPLC. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting all relevant specifications. Our production adheres to cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The material is hygroscopic (moisture-sensitive); ensure containers are kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Melting Point	88°C - 92°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.