Description

2',3'-o-(Methoxymethylene)Uridine is a protected nucleoside derivative, a crucial intermediate in organic synthesis and pharmaceutical research. This compound is specifically designed to mask the reactive hydroxyl groups of uridine, enabling selective chemical modifications for the development of novel nucleoside analogs and oligonucleotides. It is an essential building block for researchers and manufacturers in the fields of antiviral drug development, modified RNA synthesis, and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase synthesis of modified RNA strands for research and therapeutic applications.
• Medicinal Chemistry & Drug Discovery: Used to explore structure-activity relationships (SAR) by creating libraries of nucleoside derivatives.
• Biochemical Research: Employed in studies of RNA structure, function, and enzyme interactions where a protected uridine is required.
• Prodrug Development: Facilitates the creation of prodrug forms of nucleoside-based active pharmaceutical ingredients (APIs) to improve bioavailability.
• Academic & Industrial R&D: A fundamental reagent for laboratories focused on nucleic acid chemistry and life sciences.

Basic Information

Product Name	2',3'-o-(Methoxymethylene)Uridine
CAS No.	16628-81-2
Molecular Formula	C11H14N2O7
Molecular Weight	286.24 g/mol
Synonyms	2',3'-O-Methoxymethylideneuridine; Uridine, 2',3'-O-(methoxymethylene)-; 2',3'-O-MOM-uridine; 2',3'-O-(Methoxymethylene)uridine; 2',3'-Isopropylideneuridine methyl ether derivative; NSC 401071; 1-((2R,3R,4R,5R)-3,4-Bis(methoxymethoxy)-5-(methoxymethoxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (related IUPAC form)
EINECS	Contact for details

Quality Control

Our 2',3'-o-(Methoxymethylene)Uridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.