Description

N'-Nitrosonornicotine (NNN) is a nitrosamine derivative of nornicotine, a key alkaloid found in tobacco. This compound is of significant interest in toxicological and analytical research due to its role as a tobacco-specific nitrosamine (TSNA). It is primarily utilized by research institutions, analytical laboratories, and regulatory bodies focused on product safety and public health. Our supply ensures high-purity material essential for accurate scientific studies and compliance testing.

Application

• Toxicological Research: Used as a reference standard in studies investigating the carcinogenic potential and metabolic pathways of tobacco-specific nitrosamines.
• Analytical Chemistry: Serves as a critical certified reference material (CRM) for the calibration and validation of analytical methods like HPLC, GC-MS, and LC-MS/MS.
• Regulatory Compliance Testing: Essential for testing tobacco products, nicotine-containing products (e.g., e-liquids, pouches), and pharmaceutical ingredients to ensure they meet strict limits for nitrosamine impurities.
• Method Development: Employed by laboratories to develop and optimize sensitive detection techniques for nitrosamines in complex matrices.
• Quality Control & Assurance: Used as an impurity standard in the QC labs of pharmaceutical and tobacco industries to monitor and control nitrosamine levels.
• Biomarker Studies: Applied in research to understand human exposure to TSNAs and to validate biomarkers of exposure in epidemiological studies.

Basic Information

Product Name	N'-Nitrosonornicotine
CAS No.	16543-55-8
Molecular Formula	C9H11N3O
Molecular Weight	177.20 g/mol
Synonyms	NNN; 4-(Methylnitrosamino)-1-(3-pyridinyl)-1-butanone (Note: This is NNK, a common co-reference); N-Nitrosonornicotine; 1-(3-Pyridinyl)-1-butanone, 4-(methylnitrosamino)- (related); Tobacco-specific nitrosamine; TSNA; Nitrosamine impurity; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of our N'-Nitrosonornicotine is produced and handled under strict quality management protocols. The material undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques, to ensure it meets the high standards required for research and analytical applications. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at recommended cold storage conditions (e.g., -20°C or as specified on the label) to minimize degradation. The container should be kept in a cool, dry, and well-ventilated area separate from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to yellow solid / Contact for details
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Contact for higher grades)
Related Substances (HPLC)	Contact for details
Water Content (KF)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.