Description

4-Chloro-6-(Trifluoromethyl)Quinazoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a reactive chloro substituent and a stable trifluoromethyl group on the quinazoline scaffold, enabling precise molecular modifications. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors and other small-molecule therapeutic agents, particularly in oncology and anti-inflammatory drug discovery.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides by incorporating the quinazoline core and fluorine atoms for enhanced bioactivity and environmental stability.
• Material Science Research: Serves as a building block for creating advanced organic electronic materials, such as charge-transport layers or luminescent compounds.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and labeled compounds for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-Chloro-6-(Trifluoromethyl)Quinazoline
CAS No.	16499-64-2
Molecular Formula	C9H4ClF3N2
Molecular Weight	232.59 g/mol
Synonyms	4-Chloro-6-(trifluoromethyl)quinazoline; 6-(Trifluoromethyl)-4-chloroquinazoline; Quinazoline, 4-chloro-6-(trifluoromethyl)-; 4-Chloro-6-trifluoromethylquinazoline; 4-Chloro-6-trifluoromethyl-quinazoline; 16499-64-2
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-6-(Trifluoromethyl)Quinazoline is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.