Description

4-Chloro-5-(Trifluoromethyl)Quinazoline is a high-value, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which combines a reactive chloroquinazoline moiety with a stable trifluoromethyl group, enabling precise structural modifications for creating novel compounds. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the bioactivity of the quinazoline core.
• Material Science Research: Serves as a building block for creating specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and the development of molecular probes.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis projects requiring complex, fluorinated heterocycles.

Basic Information

Product Name	4-Chloro-5-(Trifluoromethyl)Quinazoline
CAS No.	16499-63-1
Molecular Formula	C9H4ClF3N2
Molecular Weight	232.59 g/mol
Synonyms	4-Chloro-5-(trifluoromethyl)quinazoline; 5-(Trifluoromethyl)-4-chloroquinazoline; 4-Chloro-5-trifluoromethylquinazoline; Quinazoline, 4-chloro-5-(trifluoromethyl)-; 16499-63-1
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-(Trifluoromethyl)Quinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.