Description

4-Chloro-7-Fluoro-Quinazoline is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its dual halogen functionality, which provides distinct reactive sites for selective cross-coupling and nucleophilic substitution reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of targeted kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other small-molecule drug candidates targeting cancer and other diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the quinazoline scaffold's bioactivity.
• Material Science Research: Serves as a building block for creating organic semiconductors, liquid crystals, and fluorescent dyes due to its conjugated aromatic system.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	4-Chloro-7-Fluoro-Quinazoline
CAS No.	16499-62-0
Molecular Formula	C8H4ClFN2
Molecular Weight	182.58 g/mol
Synonyms	7-Fluoro-4-chloroquinazoline; 4-Chloro-7-fluoroquinazoline; Quinazoline, 4-chloro-7-fluoro-; 4-Chloro-7-fluor-chinazolin (German); 4-クロロ-7-フルオロキナゾリン (Japanese); 4-氯-7-氟喹唑啉 (Chinese); 16499-62-0 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-Fluoro-Quinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material consistency and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.