Description

tert-Butyl Trimethylacetate is a specialized organic ester, also known as tert-butyl pivalate, with the CAS registry number 16474-43-4. This compound serves as a valuable building block and protecting group reagent in advanced organic synthesis, particularly for the tert-butoxycarbonyl (Boc) group. It is primarily utilized by pharmaceutical intermediates, agrochemical, and specialty chemical manufacturers who require high-purity reagents for complex synthetic pathways.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for introducing the acid- and base-stable tert-butoxycarbonyl (Boc) protecting group for amines in peptide and active pharmaceutical ingredient (API) manufacturing.
• Agrochemical Production: Used in the synthesis of advanced pesticide and herbicide intermediates that require specific steric hindrance for efficacy and stability.
• Polymer Chemistry: Acts as a monomer or initiator in the production of specialized polymers and resins, leveraging the bulky tert-butyl group to influence polymer properties.
• Organic Synthesis Reagent: Employed as a pivaloylating agent or as a source of the tert-butyl cation in various alkylation and esterification reactions under controlled conditions.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing esters with specific, non-volatile characteristics used in high-end fragrance compositions.
• Research & Development: Essential chemical for academic and industrial R&D labs exploring new synthetic methodologies and novel compound libraries.

Basic Information

Product Name	tert-Butyl Trimethylacetate
CAS No.	16474-43-4
Molecular Formula	C9H18O2
Molecular Weight	158.24 g/mol
Synonyms	tert-Butyl pivalate; Pivalic acid tert-butyl ester; 2,2-Dimethylpropanoic acid 1,1-dimethylethyl ester; Trimethylacetic acid tert-butyl ester; t-Butyl trimethylacetate; t-Butyl pivalate; tert-Butyl 2,2-dimethylpropanoate; NSC 66480
EINECS	240-522-9

Quality Control

Our tert-Butyl Trimethylacetate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, open flames, and strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.405 - 1.409
Density (20°C)	0.865 - 0.875 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.