Description

1,1'-Methylenebis(5-L-Oxoproline) is a specialized organic compound featuring a methylene bridge connecting two L-pyroglutamic acid (5-oxoproline) units. This unique structure makes it a valuable intermediate and building block in advanced chemical synthesis, particularly for creating complex molecules with specific stereochemistry. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for applications in peptide mimetics, chiral synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetics Research: Used to construct peptide-like structures that mimic natural peptides for drug discovery and biochemical studies.
• Chiral Catalyst Ligand Synthesis: Acts as a precursor for ligands used in asymmetric catalysis to produce enantiomerically pure compounds.
• Fine Chemical Synthesis: Employed in the multistep synthesis of specialty chemicals, agrochemicals, and advanced materials.
• Bioconjugation Chemistry: Potential use in linking biomolecules due to its reactive functional groups and defined stereochemistry.
• Academic & Industrial R&D: Utilized in chemical research for method development and exploring new synthetic pathways.

Basic Information

Product Name	1,1'-Methylenebis(5-L-Oxoproline)
CAS No.	16473-66-8
Molecular Formula	C12H16N2O6
Molecular Weight	284.27 g/mol
Synonyms	Bis(5-oxo-L-prolinyl)methane; 1,1'-Methylenebis(L-pyroglutamic acid); Methylenebis(5-oxo-L-proline); N,N'-Methylenedi-L-pyroglutamic acid; L-Pyroglutamic acid methylene dimer; (S,S)-1,1'-Methylenebis(5-oxopyrrolidine-2-carboxylic acid); 5-Oxo-L-proline, 1,1'-methylenebis-
EINECS	Contact for details

Quality Control

Our 1,1'-Methylenebis(5-L-Oxoproline) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical-grade intermediates. A Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S,S isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.