Description

2-(4-Nitrophenoxy)Ethanol CAS NO 16365-27-8 is a versatile aromatic ether-alcohol intermediate characterized by its nitrophenoxy functional group. This compound is valued for its role as a key building block in the synthesis of more complex molecules, particularly in fine chemical and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing active pharmaceutical ingredients (APIs) and advanced material precursors.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of various drug candidates and active pharmaceutical ingredients (APIs), particularly those requiring a phenoxyethanol backbone.
• Agrochemical Synthesis: Used in the research and development of herbicides, pesticides, and plant growth regulators where the nitrophenoxy moiety is a key structural component.
• Dye and Pigment Manufacturing: Serves as an intermediate in the production of specialized azo dyes and organic pigments, leveraging its aromatic nitro group.
• Polymer Science: Acts as a monomer or chain modifier in the synthesis of specialty polymers and resins, imparting specific chemical resistance or optical properties.
• Cross-coupling Reactions: Utilized in palladium-catalyzed reactions, such as Suzuki or Buchwald-Hartwig aminations, for constructing biaryl ether structures.
• Chemical Research: Employed in academic and industrial laboratories as a model substrate for studying etherification, reduction, and nucleophilic aromatic substitution reactions.

Basic Information

Product Name	2-(4-Nitrophenoxy)Ethanol
CAS No.	16365-27-8
Molecular Formula	C8H9NO4
Molecular Weight	183.16 g/mol
Synonyms	2-(4-Nitrophenoxy)ethan-1-ol; 4-Nitrophenoxyethanol; Ethylene glycol mono(4-nitrophenyl) ether; 2-Hydroxyethyl 4-nitrophenyl ether; 1-Hydroxy-2-(4-nitrophenoxy)ethane; p-Nitrophenoxyethanol; 4-Nitrophenoxyethyl alcohol; NSC 403697
EINECS	Contact for details

Quality Control

Our 2-(4-Nitrophenoxy)Ethanol is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications. Custom purity grades, including research and pharmaceutical intermediates, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.