Description

(3R,6R)-3,6-Bis[(Aminooxy)Methyl]-2,5-Piperazinedione is a high-purity, stereochemically defined heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique bifunctional structure, featuring two aminooxy groups attached to a piperazinedione core, which makes it a versatile intermediate for constructing complex molecular architectures. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors for applications in medicinal chemistry, peptide mimetics, and the development of novel drug conjugates and linkers.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs) and prodrugs.
• Peptide Mimetics & Conjugation: Used to create peptide analogs and for site-specific bioconjugation via its reactive aminooxy groups.
• Linker Chemistry: Serves as a bifunctional linker in antibody-drug conjugates (ADCs) and other targeted therapeutic platforms.
• Chemical Biology Probes: Employed in the development of tools for studying biological processes and protein interactions.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or template in stereoselective synthetic routes.
• Material Science Research: Investigated as a monomer or cross-linking agent for novel polymers and functional materials.

Basic Information

Product Name	(3R,6R)-3,6-Bis[(Aminooxy)Methyl]-2,5-Piperazinedione
CAS No.	16337-02-3
Molecular Formula	C8H14N4O4
Molecular Weight	230.22 g/mol
Synonyms	(3R,6R)-3,6-Bis(aminoxymethyl)-2,5-diketopiperazine; (3R,6R)-3,6-Bis(aminoxymethyl)piperazine-2,5-dione; (3R,6R)-3,6-Bis(O-aminooxymethyl)-2,5-diketopiperazine; (3R,6R)-DADOO; (3R,6R)-3,6-Di(aminoxymethyl)-2,5-piperazinedione; (3R,6R)-Bis(aminoxymethyl)DKP; 2,5-Diketopiperazine-1,4-diacetic acid diamide oxime
EINECS	Contact for details

Quality Control

Our (3R,6R)-3,6-Bis[(Aminooxy)Methyl]-2,5-Piperazinedione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); handle and store under anhydrous conditions in a desiccated environment for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.