Description

(1'-Methyl-1',2',3',4'-Tetrahydro-2H-[2,6']Biquinolinyl-1-Yl)-Phenyl-Methanone is a structurally complex biquinolinyl ketone derivative featuring a chiral tetrahydroquinoline scaffold fused to a benzophenone-like pharmacophore. This compound serves as a high-value synthetic intermediate in the development of selective kinase inhibitors and CNS-active pharmaceutical agents due to its conformationally constrained heterocyclic architecture and tunable steric-electronic profile. It is primarily utilized by research-driven pharmaceutical companies, contract development and manufacturing organizations (CDMOs), and academic medicinal chemistry laboratories engaged in oncology and neuropharmacology drug discovery programs.

Application

• Key synthetic intermediate for tyrosine kinase inhibitor candidates targeting EGFR and BTK pathways
• Chiral building block in asymmetric synthesis of neuroactive compounds for Alzheimer’s and Parkinson’s disease research
• Ligand scaffold in metal-catalyzed C–H activation methodologies for late-stage functionalization of drug candidates
• Core structure in structure-activity relationship (SAR) studies for G-protein coupled receptor (GPCR) modulators
• Reference standard for analytical method development and validation in QC laboratories
• Substrate in enzymatic transformation studies exploring cytochrome P450 metabolism profiles
• Material for crystallinity and polymorph screening during preformulation development

Basic Information

Product Name	(1'-Methyl-1',2',3',4'-Tetrahydro-2H-[2,6']Biquinolinyl-1-Yl)-Phenyl-Methanone
CAS No.	16244-74-9
Molecular Formula	C25H22N2O
Molecular Weight	374.46 g/mol
Synonyms	1-(1'-Methyl-1',2',3',4'-tetrahydro-2H-[2,6']biquinolinyl-1-yl)benzophenone; 1-(1'-Methyl-1',2',3',4'-tetrahydro-2'H-[2,6']biquinolinyl-1-yl)-1-phenylethanone (misnomer correction); NSC 127832; BQK-1278; THBQ-PhCO; Methyltetrahydrobiquinolyl phenyl ketone; (1'-Methyl-1',2',3',4'-tetrahydro-[2,6']biquinolinyl-1-yl)(phenyl)methanone; 1-(1'-Methyl-1',2',3',4'-tetrahydro-2H-2,6'-biquinolinyl-1-yl)benzophenone
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (IR, HPLC retention time, NMR spectral match), assay (≥99.0% by HPLC), residual solvents (ICH Q3C compliant), heavy metals (≤10 ppm), and optical purity (chiral HPLC, enantiomeric excess ≥99.5%). Testing adheres to ISO/IEC 17025 accredited protocols and supports GMP-compliant drug substance development.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (nitrogen or argon) to prevent oxidation. Keep away from moisture and strong oxidizing agents. Ensure adequate ventilation in storage areas.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥99.0%
Specific Rotation	[α]D20 = –12.5° to –13.5° (c = 1.0 in CHCl3)
Residual Solvents	MeOH ≤ 3000 ppm; EtOAc ≤ 5000 ppm; Heptane ≤ 5000 ppm
Heavy Metals	≤10 ppm
Water (KF)	≤0.5%
Related Substances (HPLC)	Any single impurity ≤ 0.3%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.