Description

Pyrimidine, 4-(Methylnitrosamino)- (8Ci) is a specialized nitrosamine derivative of the pyrimidine heterocycle. This compound is of significant interest in advanced chemical research and development, particularly in the study of nitrosamine chemistry and its implications. It serves as a critical reference standard and building block for researchers in pharmaceutical development, toxicology, and analytical chemistry. Its precise structure makes it valuable for method development and impurity profiling in regulated industries.

Application

• Pharmaceutical Research & Impurity Profiling: Used as a certified reference material (CRM) or analytical standard for the detection, identification, and quantification of nitrosamine impurities in active pharmaceutical ingredients (APIs) and drug products, ensuring compliance with stringent regulatory guidelines (e.g., FDA, EMA).
• Toxicological Studies: Employed in laboratory research to investigate the metabolic pathways, genotoxicity, and carcinogenic potential of nitrosamine compounds.
• Method Development & Validation: Serves as a key analyte for developing and validating highly sensitive analytical methods, such as LC-MS/MS and GC-MS, for trace-level nitrosamine analysis.
• Chemical Synthesis Intermediate: Acts as a specialized intermediate in organic synthesis for constructing complex molecules in academic and industrial research settings.
• Quality Control & Assurance: Utilized by quality control laboratories in chemical and pharmaceutical manufacturing to calibrate equipment and verify analytical procedures for nitrosamine screening.

Basic Information

Product Name	Pyrimidine, 4-(Methylnitrosamino)- (8Ci)
CAS No.	16220-54-5
Molecular Formula	C5H6N4O
Molecular Weight	138.13 g/mol
Synonyms	4-(Methylnitrosamino)pyrimidine; N-Nitroso-N-methyl-4-pyrimidinamine; 4-(N-Methyl-N-nitrosamino)pyrimidine; 4-(Methylnitrosoamino)pyrimidine; MNPA; Pyrimidine, 4-(methylnitrosamino)-; 4-Pyrimidinamine, N-methyl-N-nitroso-
EINECS	Contact for details

Quality Control

Every batch of Pyrimidine, 4-(Methylnitrosamino)- (8Ci) is manufactured and handled under strict quality management protocols. Our products undergo rigorous identity confirmation, purity analysis, and stability testing to ensure they meet the exacting standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results—including assay purity (typically by HPLC), identity confirmation (by IR/LC-MS), and related substance profiles—is provided to guarantee traceability and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (LC-MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.